Article
Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells.
Neurosurgery - 1 May 2011
Stapleton Christopher J, Armstrong Don L, Zidovetzki Raphael, Liu Charles Y, Giannotta Steven L, Hofman Florence M
Abstract excerpt
BACKGROUND: The management of cerebral arteriovenous malformation (AVM) is challenging, and invasive therapies place vital intracranial structures at risk of injury. The development of noninvasive, pharmacologic approaches relies on identifying factors that mediate key angiogenic processes. Previous studies indicate that endothelial cells (ECs) derived from cerebral AVM (AVM-ECs) are distinct from control brain...
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