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Article

Characterization of the vasculogenic block in the absence of vascular endothelial growth factor-A.

Blood - 15 Mar 2000

Bautch V L, Redick S D, Scalia A, Harmaty M, Carmeliet P, Rapoport R

Abstract excerpt

Vascular endothelial growth factor (VEGF) signaling is required for both differentiation and proliferation of vascular endothelium. Analysis of differentiated embryonic stem cells with one or both VEGF-A alleles deleted showed that both the differentiation and the expansion of endothelial cells are blocked during vasculogenesis. Blood island formation was reduced by half in hemizygous mutant VEGF cultures and by...

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Source

Identifiers

PMID: 10706864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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