Article
A dominant-negative p65 PAK peptide inhibits angiogenesis.
Circulation research - 5 Apr 2002
Kiosses William B, Hood John, Yang Suya, Gerritsen Mary E, Cheresh David A, Alderson Nazilla, Schwartz Martin Alexander
Abstract excerpt
PAK1 is a protein kinase downstream of the small GTPases Rac and Cdc42 that previous work has implicated in endothelial cell migration via modulation of cell contraction. The first proline-rich region of PAK that binds to an SH3 domain from the adapter protein NCK was responsible for these dominant-negative effects. To test the role of PAK in angiogenesis, we prepared a peptide in which the proline-rich region...
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