Article
Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995
Sheibani N, Frazier W A
Abstract excerpt
Murine endothelial cells are readily transformed in a single step by the polyomavirus oncogene encoding middle-sized tumor antigen. These cells (bEND.3) form tumors (hemangiomas) in mice which are lethal in newborn animals. The bEND.3 cells rapidly proliferate in culture and express little or no thrombospondin 1 (TS1). To determine the role of TS1 in regulation of endothelial cell phenotype, we stably transfected...
Topics
- Animals
- Cell Differentiation
- Cell Transformation, Neoplastic
- Endothelium, Vascular
- Gene Expression Regulation, Neoplastic
- Hemangioma
- Humans
- Membrane Glycoproteins
- Mice
- Neoplasms, Experimental