Article
Angiotensin II Type 1 Receptor-Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin.
Journal of the American Heart Association - 27 Jul 2017
Uneda Kazushi, Wakui Hiromichi, Maeda Akinobu, Azushima Kengo, Kobayashi Ryu, Haku Sona, Ohki Kohji, Haruhara Kotaro, Kinguchi Sho, Matsuda Miyuki, Ohsawa Masato, Minegishi Shintaro, Ishigami Tomoaki, Toya Yoshiyuki, Atobe Yoshitoshi, Yamashita Akio, Umemura Satoshi, Tamura Kouichi
Abstract excerpt
BACKGROUND: The kidney is easily affected by aging-associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis is a final common pathway in most forms of progressive renal disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP), which was originally identified as a molecule that binds to AT1R, is highly expressed...
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