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Development of progressive aortic vasculopathy in a rat model of aging

15 Sept 2007

Abstract excerpt

Recent studies have established that age is the major risk factor for vascular disease. Numerous aberrant changes occur in vascular structure and function during aging, and animal models are the primary means to determine the underlying mechanisms of age-mediated vascular pathology. The Fischer 344/Brown Norway F1 hybrid (F344xBN) rat thoracic aorta has been shown to display age-related pathology similar to what...

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PMID: 17873024
DOI: 10.1152/ajpheart.00397.2007

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