Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA.

doi:10.1074/jbc.273.47.31519

Back to search

Article

Intragenic suppressors of mutant DNA topoisomerase I-induced lethality diminish enzyme binding of DNA.

The Journal of biological chemistry - 20 Nov 1998

Hann C L, Carlberg A L, Bjornsti M A

Abstract excerpt

Eukaryotic DNA topoisomerase I (Top1p) catalyzes changes in DNA topology and is the cellular target of the antitumor drug camptothecin (Cpt). Mutation of several conserved residues in yeast top1 mutants is sufficient to induce cell lethality in the absence of camptothecin. Despite tremendous diff...

Topics

Amino Acid Sequence
Camptothecin
Catalytic Domain
Conserved Sequence
DNA Topoisomerases, Type I
Genes, Lethal
Humans
Mutation
Protein Binding
Suppression, Genetic
Topoisomerase I Inhibitors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.