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Article

The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis‐inducing stimuli

18 Mar 2003

Abstract excerpt

Testicular germ cell tumours (TGCTs) are extremely sensitive to cisplatin-containing chemotherapy. The rapid time course of apoptosis induction after exposure to cisplatin suggests that TGCT cells are primed to undergo programmed cell death as an inherent property of the cell of origin. In fact, apoptosis induction of germ cells in the testis is an important physiological mechanism to control the quality and...

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PMID: 12754734
DOI: 10.1002/path.1373

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