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Article

The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.

International journal of molecular sciences - 29 Oct 2021

Timmerman Dennis M, Eleveld Thomas F, Gillis Ad J M, Friedrichs Carlijn C, Hillenius Sanne, Remmers Tessa L, Sriram Sruthi, Looijenga Leendert H J

Abstract excerpt

Germ cell tumors (GCTs) are considered to be highly curable; however, there are major differences in the outcomes related to histology and anatomical localization. GCTs originating from the testis are, overall, sensitive to platinum-based chemotherapy, whereas GCTs originating from the mediastinum show a worse response, which remains largely unexplained. Here, we address the differences among GCTs from two...

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Topics

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Share to Antineoplastic Agents
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Mediastinal Neoplasms

Share to Neoplasms, Germ Cell and Embryonal

Share to Testicular Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 34769213
DOI: 10.3390/ijms222111774
PMCID: PMC8583723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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