Article
Apolipoprotein E epsilon4 allele is associated with vascular dementia.
Dementia and geriatric cognitive disorders - 1 Jan 2006
Baum Larry, Lam Linda C W, Kwok Timothy, Lee Jenny, Chiu Helen F K, Mok Vincent C T, Wong Adrian, Chen Xiangyan, Cheung Wing Sze, Pang Chi Pui, Ma Suk Ling, Tang Nelson L S, Wong Ka Sing, Ng Ho Keung
Abstract excerpt
BACKGROUND/AIMS: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. METHODS: We genotyped ApoE in 144 VaD patients and 251 controls. RESULTS: VaD patients were more likely than controls to have ApoE epsilon3/epsilon4 or epsilon4/epsilon4 genotypes: 23.6% versus...
Topics
- Aged
- Alleles
- Apolipoprotein E4
- Case-Control Studies
- Cerebrovascular Disorders
- DNA
- Dementia, Vascular
- Exons
- Female
- Humans
- Male