Article
Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1beta and interleukin-1 receptor antagonist and pregnancy outcome.
American journal of obstetrics and gynecology - 1 Nov 2003
Witkin Steven S, Vardhana Santosh, Yih Melissa, Doh Kunihiko, Bongiovanni Ann Marie, Gerber Stefan
Abstract excerpt
OBJECTIVE: Preterm labor in experimental models is initiated by intra-amniotic interleukin-1beta (IL-1beta) and inhibited by interleukin-1 receptor antagonist (IL-1ra). The IL-1ra gene is polymorphic and the different alleles are associated with variations in IL-1beta and IL-1ra production. The r...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.