Article
Polymorphisms in the IL-1A gene are correlated with levels of interleukin-1alpha protein in gingival crevicular fluid of teeth with severe periodontal disease.
Journal of dental research - 1 Nov 2000
Shirodaria S, Smith J, McKay I J, Kennett C N, Hughes F J
Abstract excerpt
Interleukin-1 (IL-1) is a potent stimulator of bone resorption and is strongly implicated in the destruction due to bystander damage seen in periodontal disease. Recent studies suggest that polymorphisms of the (IL-1) gene complex may be significant risk factors for a number of chronic inflammato...
Topics
- Adult
- Alleles
- Analysis of Variance
- Case-Control Studies
- Chi-Square Distribution
- Female
- Gene Frequency
- Gingival Crevicular Fluid
- Humans
- Interleukin-1
- Male
- Middle Aged
- Periodontal Diseases
- Periodontal Index
- Polymorphism, Single Nucleotide
- Risk Factors
- Smoking
- Statistics, Nonparametric