Article
Functional CD32 molecules on human NK cells.
Leukemia & lymphoma - 1 Sept 1999
Morel P A, Ernst L K, Metes D
Abstract excerpt
Human NK cells are large granular lymphocytes that kill neoplastic or virally infected targets using perforin-dependent mechanisms. CD16 or FcgammaRIII is one of the cell surface molecules that can trigger the killing machinery following binding of the Fc portion of IgG to the receptor: a mechanism known as antibody dependent cell-mediated cytotoxicity (ADCC). We have recently shown that some individuals express...
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