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Article

Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.

The Journal of biological chemistry - 5 Oct 1991

Shyamala V, Baichwal V, Beall E, Ames G F

Abstract excerpt

Traffic ATPases constitute a superfamily of transporters that include prokaryotic permeases and medically important eukaryotic proteins, such as the multidrug resistance P-glycoprotein and the cystic fibrosis gene product. We present a structure-function analysis of a member of this superfamily, the prokaryotic histidine permease, using mutations generated both in vitro and in vivo, and assaying several...

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PMID: 1717452

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