International Union of Pharmacology. LXIII. Retinoid X receptors.

doi:10.1124/pr.58.4.7

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Article

International Union of Pharmacology. LXIII. Retinoid X receptors.

Pharmacological reviews - 1 Dec 2006

Germain Pierre, Chambon Pierre, Eichele Gregor, Evans Ronald M, Lazar Mitchell A, Leid Mark, De Lera Angel R, Lotan Reuben, Mangelsdorf David J, Gronemeyer Hinrich

Abstract excerpt

The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. RARs bind both all-trans- and 9-cis-RA, whereas only the 9-cis-RA stereoisomer binds to RXRs. As RXR/RAR heterodimers, these receptors control the...

Topics

Animals
Gene Expression
Humans
Ligands
Mutation
Retinoid X Receptors
Retinoids
Terminology as Topic

Source

Open in PubMed

Identifiers

PMID: 17132853
DOI: 10.1124/pr.58.4.7

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