Article
A four-amino-acid insertion in the ligand-binding domain inactivates hRXRbeta and renders dominant negative activity.
DNA and cell biology - 1 Apr 1997
Mahajna J, Shi B, Bruskin A
Abstract excerpt
Retinoid X receptors (RXRs) are members of the steroid and thyroid hormone receptor superfamily of hormone-dependent transcription factors that mediate the pleiotropic effect of retinoids. Here, we report the initial characterization of an isoform of hRXR beta, termed hRXR beta3, which was previo...
Topics
- Alternative Splicing
- Animals
- Binding Sites
- DNA, Complementary
- DNA-Binding Proteins
- Dimerization
- Gene Library
- Humans
- Mice
- Mutation
- Protein Binding
- Protein Conformation
- Receptors, Retinoic Acid
- Recombinant Proteins
- Retinoid X Receptors
- Retinoids
- Retinol-Binding Proteins
- Retinol-Binding Proteins, Cellular