Article
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.
The EMBO journal - 1 Apr 1992
Marks M S, Hallenbeck P L, Nagata T, Segars J H, Appella E, Nikodem V M, Ozato K
Abstract excerpt
H-2RIIBP (RXR beta) is a member of the nuclear hormone receptor superfamily that activates transcription of MHC class I genes in response to retinoic acid (RA). Using chemical cross-linking, co-immunoprecipitation, gel mobility shift and streptavidin-biotin DNA precipitation assays, we show that H-2RIIBP formed heterodimers with thyroid hormone (T3) and RA receptors (T3R alpha and RAR alpha). H-2RIIBP heterodimer...
Topics
- Amino Acid Sequence
- Baculoviridae
- Base Sequence
- Carrier Proteins
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, MHC Class I
- Genetic Variation
- Humans
- Macromolecular Substances