Retinoid X receptor alpha (RXRalpha) helix 12 plays an inhibitory role in the recruitment of the p160 co-activators by unliganded RXRalpha/retinoic acid receptor alpha heterodimers.

Abstract excerpt

Retinoid X receptor (RXR)/retinoic acid receptor (RAR) heterodimers control gene expression through recruitment of co-repressors or co-activators, depending on their hormone binding status. We show that the helix 12 of RXRalpha and RARalpha is critical for recruitment of the co-regulators and transcriptional regulation by RXRalpha, RARalpha, and RXRalpha/RARalpha. LG268, an RXR-specific agonist, was able to...

Topics

• Amino Acid Sequence
• Animals
• Cell Line
• Dimerization
• Gene Deletion
• Gene Expression Regulation
• Glutathione Transferase
• Intracellular Signaling Peptides and Proteins
• Ligands
• Models, Biological
• Molecular Sequence Data
• Mutation
• Plasmids