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Article

Mutations at Pro67 in the RecA protein P-loop motif differentially modify coprotease function and separate coprotease from recombination activities.

The Journal of biological chemistry - 14 Apr 1995

Konola J T, Nastri H G, Logan K M, Knight K L

Abstract excerpt

The functional significance of residues in the RecA protein P-loop motif was assessed by analyzing 100 unique mutants with single amino acid substitutions in this region. Comparison of the effects on the LexA coprotease and recombination activities shows that Pro67 is unique among these residues...

Topics

Amino Acid Sequence
Bacterial Proteins
Endopeptidases
Hydrolysis
Molecular Sequence Data
Mutation
Nucleic Acids
Proline
Rec A Recombinases
Recombination, Genetic
Repressor Proteins
Serine Endopeptidases

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Identifiers

PMID: 7721735
DOI: 10.1074/jbc.270.15.8411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7721735-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mutations at Pro67 in the RecA protein P-loop motif differentially modify coprotease function and separate coprotease from recombination activities.PMID 7721735Read ↗

Biochemical basis of the constitutive coprotease activity of RecA P67W protein.Semantic proximity Read ↗

New mutations in and around the L2 disordered loop of the RecA protein modulate recombination and/or coprotease activity.Semantic proximity Read ↗

Functional characterization of residues in the P-loop motif of the RecA protein ATP binding site.Semantic proximity Read ↗

Genetical and biochemical evidence for the involvement of the coprotease domain of Escherichia coli RecA protein in recombination.Semantic proximity Read ↗

Molecular design and functional organization of the RecA protein.Semantic proximity Read ↗

Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA.Semantic proximity Read ↗

Genetic dissection of the biochemical activities of RecBCD enzyme.Semantic proximity Read ↗

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