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Article

Mutant LexA proteins with an increased rate of in vivo cleavage.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991

Smith M H, Cavenagh M M, Little J W

Abstract excerpt

LexA repressor of Escherichia coli is inactivated by a specific cleavage reaction that requires activated RecA protein in vivo. This cleavage reaction can proceed in vitro in the presence of activated RecA or as an intramolecular RecA-independent reaction, termed autodigestion, that is stimulated by alkaline pH. Here we describe a set of LexA mutant proteins that undergo a greatly increased rate of specific...

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Identifiers

PMID: 1908093
DOI: 10.1073/pnas.88.16.7356
PMCID: PMC52294

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Mutant LexA proteins with an increased rate of in vivo cleavage.PMID 1908093Read ↗

In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage.Semantic proximity Read ↗

LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.Semantic proximity Read ↗

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Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.Semantic proximity Read ↗

Regulation of the SOS response in Bacillus subtilis: evidence for a LexA repressor homolog.Semantic proximity Read ↗

Characterization of RecA1332 in vivo and in vitro. A role for alpha-helix E as a liaison between the subunit-subunit interface and the DNA and ATP binding domains of RecA protein.Semantic proximity Read ↗

Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction.Semantic proximity Read ↗

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Purification and biochemical characterization of Escherichia coli RecA proteins mutated in the putative DNA binding site.Semantic proximity Read ↗

LexA protein of cyanobacterium Anabaena sp. strain PCC7120 exhibits in vitro pH-dependent and RecA-independent autoproteolytic activity.Semantic proximity Read ↗

Proteolytic activation of UmuD and MucA proteins for SOS mutagenesis.Semantic proximity Read ↗

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