Article
The antibiotic micrococcin acts on protein L11 at the ribosomal GTPase centre.
Journal of molecular biology - 19 Mar 1999
Porse B T, Cundliffe E, Garrett R A
Abstract excerpt
Micrococcin-resistant mutants of Bacillus megaterium that carry mutations affecting ribosomal protein L11 have been characterised. The mutants fall into two groups. "L11-minus" strains containing an L11 gene with deletions, insertions or nonsense mutations which grow 2.5-fold slower than the wild-type strain, whereas other mutants carrying single-site substitutions within an 11 amino acid residue segment of the...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Bacillus megaterium
- Bacteriocins
- Base Sequence
- Binding Sites
- Cloning, Molecular
- Drug Resistance, Microbial
- Fusidic Acid
- GTP Phosphohydrolases
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Synthesis Inhibitors
- Pyridones
- RNA, Ribosomal, 23S
- RNA-Binding Proteins
- Recombinant Fusion Proteins