Article
Altered topographic expression of p21WAF1/CIP1/SDI1, bcl2 and p53 during gastric carcinogenesis.
Pathology, research and practice - 1 Jan 1998
Cho J H, Kim W H
Abstract excerpt
The accumulation of wild-type p53 protein results in two pathways, cell cycle G1 arrest by p21WAF1/CIP1/SDI1 and apoptosis inhibited by bcl2, which together carry out the tumor suppressor function. Since genetic alterations of p53 are frequently observed in gastric cancers, the expression of p21...
Topics
- Adenocarcinoma
- Adenoma
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Gastric Mucosa
- Gene Expression Regulation, Neoplastic
- Genes, bcl-2
- Genes, p53
- Humans
- Immunohistochemistry
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Polyps
- Stomach Neoplasms