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Article

[MTHFR genetic variability on coronary artery disease development].

Revista da Associacao Medica Brasileira (1992) - 1 Jan 2000

Biselli Patrícia Matos, Guerzoni Alexandre Rodrigues, Goloni-Bertollo Eny Maria, Godoy Moacir Fernandes de, Abou-Chahla Juliana Aparecida Barcelos, Pavarino-Bertelli Erika Cristina

Abstract excerpt

OBJECTIVE: Increased homocysteine (Hcy) concentration is considered a risk factor for coronary artery disease (CAD). Genetic alterations of the metylenetetrahydrofolate reductase (MTHFR) enzyme could reduce its thermolability and alter the Hcy metabolism, contributing to development of atherosclerotic lesions. Objective of this study was to investigate the relation between MTHFR C677T and A1298C polymorphisms and...

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Source

Identifiers

PMID: 19629345
DOI: 10.1590/s0104-42302009000300018

Genes

MTHFR
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[MTHFR genetic variability on coronary artery disease development].PMID 19629345Read ↗

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Association of the methylene-tetrahydrofolate reductase gene rs1801133 C677T variant with serum homocysteine levels, and the severity of coronary artery disease.Semantic proximity Read ↗

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