Article
Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2009
Hajihosseini Mohammad K, Duarte Raquel, Pegrum Jean, Donjacour Anne, Lana-Elola Eva, Rice David P, Sharpe James, Dickson Clive
Abstract excerpt
Apert syndrome (AS) is a severe congenital disease caused by mutations in fibroblast growth factor receptor-2 (FGFR2), and characterised by craniofacial, limb, visceral, and neural abnormalities. AS-type FGFR2 molecules exert a gain-of-function effect in a ligand-dependent manner, but the causative FGFs and their relative contribution to each of the abnormalities observed in AS remains unknown. We have generated...
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