Article
Identification of a domain within the human T-cell leukemia virus type 2 envelope required for syncytium induction and replication.
Journal of virology - 1 Mar 1998
Poon B, Chen I S
Abstract excerpt
In vitro infection by human T-cell leukemia virus type 1 and 2 (HTLV-1 and HTLV-2) can result in syncytium formation, facilitating viral entry. Using cell lines that were susceptible to HTLV-2-mediated syncytium formation but were nonfusogenic with HTLV-1, we constructed chimeric envelopes between HTLV-1 and -2 and assayed for the ability to induce syncytia in BJAB cells and HeLa cells. We have identified a...
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