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Article

TR1.3 viral pathogenesis and syncytium formation are linked to Env-Gag cooperation.

Journal of virology - 1 Oct 2007

Murphy Samuel L, Gaulton Glen N

Abstract excerpt

Infection with murine leukemia virus (MLV) TR1.3 or the related molecular construct W102G causes severe neuropathology in vivo. Infection is causally linked to the development of extensive syncytia in brain capillary endothelial cells (BCEC). These viruses also induce cell fusion of murine cell lines, such as SC-1 and NIH 3T3, which are otherwise resistant to MLV-induced syncytium formation. Although the...

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Identifiers

PMID: 17634219
DOI: 10.1128/JVI.00816-07
PMCID: PMC2045439

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Source receipt: pubmed, retrieved 7 Sept 2026.

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