Article
Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Freed E O, Myers D J, Risser R
Abstract excerpt
The human immunodeficiency virus transmembrane glycoprotein gp41 has at its amino terminus a strongly hydrophobic stretch of 28 amino acids flanked by a highly conserved series of polar amino acids. To investigate the role in syncytium formation of the hydrophobic amino terminus of gp41 and the polar border of this hydrophobic region, we introduced eight single-amino acid substitutions and one double-amino acid...
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