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Article

Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein.

The Journal of biological chemistry - 13 Mar 1998

Stefansson S, Muhammad S, Cheng X F, Battey F D, Strickland D K, Lawrence D A

Abstract excerpt

Much of the controversy surrounding the binding of plasminogen activator inhibitor-1 (PAI-1) to the low density lipoprotein receptor-related protein (LRP) may be due to the labile structure of PAI-1 and the distinct conformations that it can adopt. To examine this possibility and to test the hypothesis that PAI-1 contains a specific high affinity binding site for LRP, a sensitive and quantitative assay for PAI-1...

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Identifiers

PMID: 9497365
DOI: 10.1074/jbc.273.11.6358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein.PMID 9497365Read ↗

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The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.Semantic proximity Read ↗

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The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitorsSemantic proximity Read ↗

Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain.Semantic proximity Read ↗

Three Decades of Research on Plasminogen Activator Inhibitor-1: A Multifaceted SerpinSemantic proximity Read ↗

Unexpected Role of Plasminogen Activator Inhibitor 1 in Cell Adhesion and DetachmentSemantic proximity Read ↗

Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal.Semantic proximity Read ↗

Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.Semantic proximity Read ↗

Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure.Semantic proximity Read ↗

Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type-1 plasminogen activator inhibitor complex.Semantic proximity Read ↗

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