Article
Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein.
The Journal of biological chemistry - 13 Mar 1998
Stefansson S, Muhammad S, Cheng X F, Battey F D, Strickland D K, Lawrence D A
Abstract excerpt
Much of the controversy surrounding the binding of plasminogen activator inhibitor-1 (PAI-1) to the low density lipoprotein receptor-related protein (LRP) may be due to the labile structure of PAI-1 and the distinct conformations that it can adopt. To examine this possibility and to test the hypothesis that PAI-1 contains a specific high affinity binding site for LRP, a sensitive and quantitative assay for PAI-1...
Topics
- Animals
- Binding Sites
- Binding, Competitive
- Biological Transport
- Endocytosis
- Low Density Lipoprotein Receptor-Related Protein-1
- Mice
- Mutation
- Plasminogen Activator Inhibitor 1
- Plasminogen Activators