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Article

The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.

The Journal of biological chemistry - 21 May 2004

Degryse Bernard, Neels Jaap G, Czekay Ralf-Peter, Aertgeerts Kathleen, Kamikubo Yu-Ichi, Loskutoff David J

Abstract excerpt

Although plasminogen activator inhibitor-1 (PAI-1) is known to stimulate cell migration, little is known about underlying mechanisms. We show that both active and inactive (e.g. cleaved) PAI-1 can activate the Jak/Stat signaling system and stimulate cell migration in chemotaxis, haptotaxis, chemokinesis, and wound healing assays. Moreover, antibodies to the LDL receptor-related protein (LRP) and an LRP antagonist...

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Identifiers

PMID: 15001579
DOI: 10.1074/jbc.M313004200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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