Article
Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: a population-based study.
Cancer research - 15 Apr 1999
Armes J E, Trute L, White D, Southey M C, Hammet F, Tesoriero A, Hutchins A M, Dite G S, McCredie M R, Giles G G, Hopper J L, Venter D J
Abstract excerpt
Breast cancers arising in women with and without a germline mutation in the BRCA1 or BRCA2 gene display different histological features, which suggests unique mechanisms of molecular pathogenesis: We used a molecular pathological analysis to define the genetic abnormalities relevant to these specific pathogeneses. Tumor material was studied from 40 women with breast cancer diagnosed before 40 years of age,...
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