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Article

A gain-of-function mutation in STAT6.

The Journal of biological chemistry - 12 May 2000

Daniel C, Salvekar A, Schindler U

Abstract excerpt

Interleukin-4 (IL-4) is a cytokine that plays a crucial role in the pathophysiology of asthma and allergic diseases. IL-4-induced gene expression is largely mediated through the activation of the latent transcription factor STAT6. We identified a STAT6 mutant (STAT6VT)) that is activated independently of IL-4 stimulation. STAT6VT carries two amino acid changes in the SH2 domain that affect the overall structure...

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Source

Identifiers

PMID: 10747856
DOI: 10.1074/jbc.c000129200

Genes

STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A gain-of-function mutation in STAT6.PMID 10747856Read ↗

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STAT5b: A master regulator of key biological pathwaysSemantic proximity Read ↗

Autosomal Dominant STAT6 Gain of Function Causes Severe Atopy Associated with LymphomaSemantic proximity Read ↗

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6Semantic proximity Read ↗

A partial loss-of-function variant in STAT6 protects against type 2 asthma.Semantic proximity Read ↗

A novel gain-of-function mutation in STAT5B is associated with treatment-resistant severe atopic dermatitis.Semantic proximity Read ↗

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.Semantic proximity Read ↗

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