Article
Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain.
Respiratory research - 1 Jan 2002
Kruse Susanne, Braun Sandra, Deichmann Klaus A
Abstract excerpt
BACKGROUND: Although IL-4 and IL-13 share the IL-13 receptor, IL-13 exhibits unique functions. To elicit the cellular basis of these differences, signal transduction processes have been compared. Additionally, the role of the IL-4 receptor alpha (IL-4Ralpha) variant Q551R was investigated. METHODS: Peripheral blood mononuclear cells from donors were stimulated with IL-4 and IL-13. The phosphorylation status of...
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