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Article

Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2004

Ocaranza María Paz, Díaz-Araya Guillermo, Carreño Juan E, Muñoz David, Riveros Juan Pablo, Jalil Jorge E, Lavandero Sergio

Abstract excerpt

In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene polymorphism among strains with different ACE levels. We tested the hypothesis that this ACE gene polymorphism determines the extent of cardiac fibrosis induced by isoproterenol (Iso) in the rat....

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Identifiers

PMID: 14527934
DOI: 10.1152/ajpheart.00102.2003

Genes

ACE
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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