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The partial tandem duplication of <i>ALL1</i> ( <i>MLL</i> ) is consistently generated by <i>Alu-</i> mediated homologous recombination in acute myeloid leukemia

3 Mar 1998

Abstract excerpt

Chromosome abnormalities resulting in gene fusions are commonly associated with acute myeloid leukemia (AML), however, the molecular mechanism(s) responsible for these defects are not well understood. The partial tandem duplication of the ALL1 (MLL) gene is found in patients with AML and trisomy 11 as a sole cytogenetic abnormality and in 11% of patients with AML and normal cytogenetics. This defect results from...

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Share to Acute Lymphoblastic Leukemia research
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Share to Genomic variations and chromosomal abnormalities

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PMID: 9482895
DOI: 10.1073/pnas.95.5.2390

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The partial tandem duplication of <i>ALL1</i> ( <i>MLL</i> ) is consistently generated by <i>Alu-</i> mediated homologous recombination in acute myeloid leukemiaPMID 9482895Read ↗

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