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Genomic DNA breakpoints in <i>AML1</i> / <i>RUNX1</i> and <i>ETO</i> cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia

26 Feb 2002

Abstract excerpt

The translocation t(8;21)(q22;q22) is one of the most frequent chromosome translocations in acute myeloid leukemia (AML). AML1/RUNX1 at 21q22 is involved in t(8;21), t(3;21), and t(16;21) in de novo and therapy-related AML and myelodysplastic syndrome as well as in t(12;21) in childhood B cell acute lymphoblastic leukemia. Although DNA breakpoints in AML1 and ETO (at 8q22) cluster in a few introns, the mechanisms...

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PMID: 11867721
DOI: 10.1073/pnas.042702899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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