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Article

ALL-1 partial duplication in acute leukemia.

21 Jun 1994

Abstract excerpt

The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations present in 5-10% of human acute leukemias. We have recently reported the detection by Southern blot of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations. These include 2 of 19 patients with normal karyotypes as...

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Identifiers

PMID: 8016145
DOI: 10.1073/pnas.91.13.6236

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ALL-1 partial duplication in acute leukemia.PMID 8016145Read ↗

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome.Semantic proximity Read ↗

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancySemantic proximity Read ↗

Exon/intron structure of the human ALL‐1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemiasSemantic proximity Read ↗

ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemiaSemantic proximity Read ↗

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23.Semantic proximity Read ↗

The partial tandem duplication of <i>ALL1</i> ( <i>MLL</i> ) is consistently generated by <i>Alu-</i> mediated homologous recombination in acute myeloid leukemiaSemantic proximity Read ↗

Multigenetic lesions in infant acute leukaemias: correlations with ALL-1 gene status.Semantic proximity Read ↗

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.Semantic proximity Read ↗

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.Semantic proximity Read ↗

Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy DonorsSemantic proximity Read ↗

Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemiaSemantic proximity Read ↗

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneSemantic proximity Read ↗

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