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Article

Alu elements mediate <i>MYB</i> gene tandem duplication in human T-ALL

10 Dec 2007

Abstract excerpt

Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats and that the duplication is mediated somatically by homologous recombination between the flanking Alu elements on sister chromatids. Nested long-range PCR analysis indicated a low frequency of homologous...

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PMID: 18070937
DOI: 10.1084/jem.20071637

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