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The Translocation (6;9), Associated with a Specific Subtype of Acute Myeloid Leukemia, Results in the Fusion of Two Genes, <i>dek</i> and <i>can</i> , and the Expression of a Chimeric, Leukemia-Specific <i>dek-can</i> mRNA

1992-04-01

Abstract excerpt

The translocation (6;9) is associated with a specific subtype of acute myeloid leukemia (AML). Previously, it was found that breakpoints on chromosome 9 are clustered in one of the introns of a large gene named Cain (can). cDNA probes derived from the 3' part of can detect an aberrant, leukemia-specific 5.5-kb transcript in bone marrow cells from t(6;9) AML patients. cDNA cloning of this mRNA revealed that it is a...

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Literature Corpus work
287273dc-c0fd-5980-af65-d472a9277694
DOI
10.1128/mcb.12.4.1687-1697.1992
Open publication

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The Translocation (6;9), Associated with a Specific Subtype of Acute Myeloid Leukemia, Results in the Fusion of Two Genes, <i>dek</i> and <i>can</i> , and the Expression of a Chimeric, Leukemia-Specific <i>dek-can</i> mRNADOI 10.1128/mcb.12.4.1687-1697.1992
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.Semantic proximity
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