Article
The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997
Caligiuri M A, Strout M P, Oberkircher A R, Yu F, de la Chapelle A, Bloomfield C D
Abstract excerpt
The molecular defects responsible for tumorigenesis in adult de novo acute myeloid leukemia (AML) with a normal karyotype or an additional copy of one chromosome (i.e., trisomy) remain largely unknown. We recently discovered that approximately 90% of adult patients with de novo AML and trisomy 11 (+11) as a sole abnormality and 11% of adult patients with de novo AML and normal cytogenetics carry a molecular...
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