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Article

Identification of complex genomic breakpoint junctions in the t(9;11) <i>MLL‐AF9</i> fusion gene in acute leukemia

1 Oct 1997

Abstract excerpt

The MLL gene at chromosome 11, band q23, is involved in translocations with as many as 40 different chromosomal bands. Virtually all breakpoints occur within an 8.3 kb BamHI fragment and result in 5' MLL fused to partner genes in a 5'-3' orientation. The translocation t(9;11)(p22;q23), which results in the fusion of MLL to AF9, is the most common of the 11q23 chromosomal abnormalities observed in de novo acute...

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Identifiers

PMID: 9331569
DOI: 10.1002/(sici)1098-2264(199710)20:2<185::aid-gcc9>3.0.co;2-#

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Related research

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Identification of complex genomic breakpoint junctions in the t(9;11) <i>MLL‐AF9</i> fusion gene in acute leukemiaPMID 9331569Read ↗

Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy‐related AML after treatment without etoposidesSemantic proximity Read ↗

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Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal TranslocationsSemantic proximity Read ↗

The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.Semantic proximity Read ↗

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