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Article

Clathrin self-assembly is regulated by three light-chain residues controlling the formation of critical salt bridges.

The EMBO journal - 10 Aug 1998

Ybe J A, Greene B, Liu S H, Pley U, Parham P, Brodsky F M

Abstract excerpt

Clathrin self-assembly into a polyhedral lattice mediates membrane protein sorting during endocytosis and organelle biogenesis. Lattice formation occurs spontaneously in vitro at low pH and, intracellularly, is triggered by adaptors at physiological pH. To begin to understand the cellular regulation of clathrin polymerization, we analyzed molecular interactions during the spontaneous assembly of recombinant hub...

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Identifiers

PMID: 9482727
DOI: 10.1093/emboj/17.5.1297
PMCID: PMC1170478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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