Article

Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

2019-06-21

Abstract excerpt

<h4>SUMMARY</h4> Force generation due to actin assembly is a fundamental aspect of membrane sculpting for many essential processes. In this work, we use a multiscale computational model constrained by experimental measurements to show that a minimal branched actin network is sufficient to internalize endocytic pits against physiological membrane tension. A parameter sweep identified the number of Arp2/3 complexes...

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Literature Corpus work: 7568a9f3-9f49-5ecb-b4e2-7946838882b6
DOI: 10.1101/678797

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