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Article

Open-channel block of Na+ channels by intracellular Mg2+.

European biophysics journal : EBJ - 1 Jan 1990

Pusch M

Abstract excerpt

1. Macroscopic and single-channel currents through several types of cloned rat brain Na+ channels, expressed in Xenopus oocytes, were measured using the patch-clamp technique. 2. For all cloned channel types and for endogenous Na+ channels in chromaffin cells, intracellular Mg2+ blocks outward currents in a voltage-dependent manner similar to that in rat brain type II Na+ channel (Pusch et al. 1989). 3. A...

Topics

Action Potentials
Analysis of Variance
Animals
Electric Conductivity
In Vitro Techniques
Magnesium
Models, Biological
Mutation
Oocytes
Rats
Recombinant Proteins
Sodium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sodium Channels

Xenopus

Source

Identifiers

PMID: 2170102
DOI: 10.1007/BF00196922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170102-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Open-channel block of Na+ channels by intracellular Mg2+.PMID 2170102Read ↗

Lack of negatively charged residues at the external mouth of Kir2.2 channels enable the voltage-dependent block by external Mg2+.Semantic proximity Read ↗

Intracellular Mg2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel.Semantic proximity Read ↗

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.Semantic proximity Read ↗

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Internal Mg2+ block of recombinant NMDA channels mutated within the selectivity filter and expressed in Xenopus oocytes.Semantic proximity Read ↗

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Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.Semantic proximity Read ↗

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