Article
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
The Journal of biological chemistry - 27 Feb 1998
Kanda Y, Mitani K, Kurokawa M, Yamagata T, Yazaki Y, Hirai H
Abstract excerpt
The MEN gene (also called ELL) encodes an RNA polymerase II elongation factor that has been implicated in t(11;19)(q23;p13.1) translocation in myeloid leukemias. The function of another elongation factor, elongin, is known to be inhibited by VHL tumor suppressor protein in vitro, suggesting the possible relationship of aberrant transcriptional elongation to oncogenesis. We overexpressed the MEN protein in Rat1...
Topics
- 3T3 Cells
- Animals
- Cell Nucleus
- Cell Transformation, Neoplastic
- Cells, Cultured
- DNA-Binding Proteins
- Epidermal Growth Factor
- Fibroblasts
- Gene Expression
- Gene Transfer Techniques
- Humans
- Leukemia, Myeloid
- Lysine