Article
Inhibition of transcription elongation by the VHL tumor suppressor protein.
Science (New York, N.Y.) - 8 Sept 1995
Duan D R, Pause A, Burgess W H, Aso T, Chen D Y, Garrett K P, Conaway R C, Conaway J W, Linehan W M, Klausner R D
Abstract excerpt
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central nervous system, and pheochromocytoma. Here, a cellular transcription factor, Elongin (SIII), is identified as a functional target of the VHL protein. Elongin (SIII) is a heterotrimer consisting of a transcriptionally active subunit (A)...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cloning, Molecular
- Elongin
- Gene Expression Regulation
- Genes, Tumor Suppressor
- HeLa Cells
- Humans
- Ligases
- Molecular Sequence Data