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Article

The multiple endocrine neoplasia type 1 gene product, menin, inhibits the human prolactin promoter activity

1 Dec 2002

Abstract excerpt

Menin is a protein encoded by the gene mutated in multiple endocrine neoplasia type 1 (MEN1) characterized by multiple endocrine tumors of the parathyroid glands, pancreatic islets and the anterior pituitary, especially prolactinoma. In this study, we examined the effects of menin on human prolactin (hPRL) expression. In rat pituitary GH3 cells stably expressing menin, both PRL gene expression/secretion and...

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PMID: 12459032
DOI: 10.1677/jme.0.0290297

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