Article
Interaction between pseudorabies virus and heparin/heparan sulfate. Pseudorabies virus mutants differ in their interaction with heparin/heparan sulfate when altered for specific glycoprotein C heparin-binding domain.
The Journal of biological chemistry - 27 Feb 1998
Trybala E, Bergström T, Spillmann D, Svennerholm B, Flynn S J, Ryan P
Abstract excerpt
Cell surface heparan sulfate serves as an initial receptor for a number of herpesviruses including pseudorabies virus (PrV). It has been demonstrated that the heparan sulfate-binding domain of PrV glycoprotein C is composed of three discrete clusters of basic residues corresponding to amino acids...
Topics
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Binding Sites
- Cells, Cultured
- Dogs
- Heparin
- Heparitin Sulfate
- Herpesvirus 1, Suid
- Kidney
- Molecular Sequence Data
- Mutation
- Oligosaccharides
- Receptors, Virus
- Viral Envelope Proteins