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Article

The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site.

The Journal of biological chemistry - 30 May 2008

Crublet Elodie, Andrieu Jean-Pierre, Vivès Romain R, Lortat-Jacob Hugues

Abstract excerpt

It is well established that the human immunodeficiency virus-1 envelope glycoprotein surface unit, gp120, binds to cell-associated heparan sulfate (HS). Virus infectivity is increased by such interaction, and a variety of soluble polyanions efficiently neutralize immunodeficiency virus-1 in vitro. This interaction has been mainly attributed to the gp120 V3 loop. However, although evidence suggested that this...

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Identifiers

PMID: 18378683
DOI: 10.1074/jbc.M800066200
PMCID: PMC3258890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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