Article
An N-end rule destabilization mutant reveals pre-Golgi requirements for Sec7p in yeast membrane traffic.
Biochemical and biophysical research communications - 4 Feb 1998
Wolf J, Nicks M, Deitz S, van Tuinen E, Franzusoff A
Abstract excerpt
Sec7 protein (Sec7p) is required for membrane traffic in the yeast secretory pathway. Because Sec7p regulates more than one stage in the pathway, it has been difficult to assign the most proximal requirement for Sec7p action. We have engineered a novel mutant whose Sec7p levels are regulated by growth conditions and by selective protein destabilization according to the N-end rule. Sec7p depletion causes cell...
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