Measles Virus Contact with T Cells Impedes Cytoskeletal Remodeling Associated with Spreading, Polarization, and CD3 Clustering

Abstract excerpt

CD3/CD28-induced activation of the PI3/Akt kinase pathway and proliferation is impaired in T cells after contact with the measles virus (MV) glycoprotein (gp) complex. We now show that this signal also impairs actin cytoskeletal remodeling in T cells, which loose their ability to adhere and to promote microvilli formation. MV exposure results in an almost complete collapse of membrane protrusions associated with...

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